Lithium Orotate for Alzheimer's
Interest in lithium orotate for Alzheimer's stems from studies on lithium’s effects on pathways involved in neuroprotection (e.g. GSK-3). Prescription lithium carbonate has been studied more than lithium orotate; human trials of lithium orotate specifically for Alzheimer’s are not established. This page is an educational overview—not medical advice.
Research context
Some preclinical and observational research has looked at lithium and cognitive outcomes. Lithium orotate is an OTC form; the 2021 review “Lithium orotate: A superior option for lithium therapy?” notes that evidence for lithium orotate in Alzheimer’s is limited and calls for more research. See our Pacholko 2021 review (PDF) and blog for deeper reading.
Brain health and dosage
If you are considering any lithium-containing product for brain health or Alzheimer’s, discuss best dosage for humans and safety with a clinician. Learn more about lithium orotate supplements for human brain health on our site.